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Gut microbes could protect us from toxic ‘forever chemicals’

1 Jul , 2025

Researchers at the University of Cambridge have identified a group of gut bacteria capable of absorbing harmful PFAS chemicals also known as forever chemicals from their surroundings. When nine of these bacterial species were introduced into mice to simulate a human gut microbiome the microbes quickly absorbed PFAS consumed by the mice which were then eliminated through their feces.

Remarkably even as PFAS exposure increased the bacteria maintained consistent removal efficiency soaking up between 25% and 74% of the toxic compounds within minutes of exposure.

This study provides the first evidence that the gut microbiome may aid in eliminating PFAS from the body though human trials have yet to be conducted. The researchers now aim to develop probiotic supplements designed to boost these beneficial microbes offering a potential new strategy to protect against PFAS-related health risks.

PFAS are nearly impossible to avoid in today’s world. These synthetic chemicals are widely used in everyday items like non-stick cookware waterproof clothing cosmetics and food packaging due to their resistance to heat, water, oil, and grease. However because they take thousands of years to degrade PFAS have been steadily accumulating in the environment and in our bodies.

Dr. Kiran Patil from the University of Cambridge’s MRC Toxicology Unit senior author of the study remarked: Considering the widespread presence and health risks of PFAS it’s alarming how little is being done to remove them from the human body.

The research revealed that certain human gut bacteria can absorb large amounts of PFAS across different concentrations and store them in clusters inside their cells. This aggregation appears to shield the bacteria from PFAS toxicity.

Dr. Indra Roux co-author of the study emphasized: PFAS are already embedded in our environment and in our bodies we must now focus on minimizing their health impact. While we haven’t yet discovered a way to destroy PFAS our research offers a promising path to help clear them from the human body where they pose the greatest threat.

Source: https://www.cam.ac.uk/research/news/gut-microbes-could-protect-us-from-toxic-forever-chemicals


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